Junior Laboratory Analyst (P001461)
Listing reference: nwu_002187
Listing status: Closed
Apply by: 10 November 2023
Position summary
Industry: Education & Training
Job category: Others: Education and Training
Location: Potchefstroom
Contract: Fixed Term Contract
Remuneration: The annual total remuneration package will be commensurate with the level of appointment as advertised and in line with the NWU policy guidelines.
About our company
NWU
Introduction
NORTH-WEST UNIVERSITY (POTCHEFSTROOM CAMPUS)
FACULTY OF HEALTH SCIENCES
PC CENTRE FOR PHARMACEUTICAL AND BIOMEDICAL SERVICES
POSITION NUMBER: P001461
VACANCY: JUNIOR LABORATORY ANALYST
PEROMNES GRADE: 13
EMPLOYMENT TYPE: FIXED-TERM APPOINTMENT
PURPOSE OF THE POSITION
Generate Quality Control testing results by performing various pharmaceutical analyses, using HPLC and GC, according to specific analytical procedures and a defined Quality Management System
Job description
KEY RESPONSIBILITIES:
Performing analyses in HPLC/GC laboratory
1. HPLC analysis:
- Daily environmental monitoring: Perform /verify that temperature measurements are performed, documented and valid before using an area.
- Daily water quality monitoring: Perform /verify that water quality measurements are performed, documented and within valid range before using water
- Daily pH calibration and measurements: Perform /verify pH calibration and validity before pH measurements/adjustments
- Daily balance verifications: Perform /verify that daily balance verifications are performed, documented and valid before using balance.
- Plan, prepare and document preparation of mobile phase, diluent/solvent, buffer solutions, test solutions and reference solutions according to method of analysis and QMS
- Prepare HPLC and column for analysis – also see maintaining HPLC columns and systems
- Perform pre-run injections and check system suitability requirements
- Analyse prepared solutions on HPLC sequence and report results for evaluation – also see administrative tasks
- After completion of analysis safely discard generated waste in the correct waste containers
- Participation and documentation of analytical investigations, deviations and CAPA’s when incident/non-conforming work is identified
- For some dosage forms, performing and reporting of visual examination of the product might be required
- Assisting other HPLC analysts with their duties to increase overall effectiveness within the HPLC laboratory
2. GC analysis:
- Plan, prepare and document preparation of diluent/solvent, buffer solutions, test solutions and reference solutions according to method of analysis and QMS.
- Prepare GC and column for analysis – also see maintaining HPLC / GC columns and systems.
- Perform pre-run injections and check system suitability requirements.
- Analyse prepared solutions on GC sequence and report results for evaluation – also see administrative tasks.
- After completion of analysis safely discard generated waste in the correct waste containers.
- Participation and documentation of analytical investigations, deviations and CAPA’s when incident/non-conforming work is identified
- For some dosage forms, performing and reporting of visual examination of the product might be required.
Maintaining HPLC /GC columns and HPLC / GC systems
1. Ensure that HPLC/GC systems and HPLC/GC columns are properly maintained:
- Report HPLC system to equipment supervisor whenever maintenance is required or if the calibration expired.
- Without compromising the analytical column, ensure that the HPLC system with all solvent lines is flushed with water (using provided link) at least once a week (more frequently if high concentration buffers were used).
- Before each analysis, rinse the HPLC with rinsing solution (debuffered mobile phase) to remove any salt or incompatible solvents, followed by rinsing the column with rinsing solution to remove the storage solution of the column.
- Gradually increasing the flow rate through the column until the desired flow is reached.
- After analysis rinse the HPLC system and column with rinsing solution, perform column test, and store column in specified storage solution.
- Ensure that sufficient seal wash is available, and that seal wash is always flowing.
- Ensure that HPLC system is properly stored until the next analysis – that the system will not run dry while idle.
- Clean the dust or any salt build-up that formed from the HPLC system (including solvent tray) once a week.
2. Ensure that GC systems and GC columns are properly maintained:
- Report GC system to equipment supervisor whenever maintenance is required or if the calibration expired.
- Bake out column and GC system before analysis and after analysis according to the column maximum temperature.
Ensure that GC system is properly stored until the next analysis – maintaining gas flow on system and reporting when gas runs empty to relevant person for replacement. Clean the dust from the GC system once a week.
Administrative tasks
1. Completing all documentation and logbooks according to cGMP and ALCOA required for calculation and reporting of HPLC/GC
results:
- Analytical planning completed, verified proof of implementation initialled.
- HPLC/GC logbook completed and verified, retention times of active substances (reference standard and samples) noted, logbook references completed, all printouts pasted into logbook, open spaces completed or cancelled.
- Information on HPLC/GC sequence and processing method completed and verified where applicable.
- All relevant results or supporting documentation printed,signed (if applicable) and submitted for evaluation.
2. Implementation of RIIP/CENQAM quality system:
- Knowledge, comprehension and adherence to the quality system of RIIP/CENQAM.(Quality Manual)
- Recognise / identify and report deviations and analytical errors to section head.
- Assist with root causes analysis during analytical investigations and deviations.
- Continuous competence evaluations / tests with regards to
- SANAS documents, cGMP and ISO17025 requirements and RIIP/CENQAM procedures like the Quality Manual.
- Proficiency testing.
- Follow standard operating procedures.
Occupational Health and safety
1. Management of laboratory OHS as required by policies and procedures.Promoting Responsible and safe working practises:
- Demonstrate an ethic of care
- Compliance with national OHS legislation, NWU and FHS OHS rules and guidelines
- Adequately trained on safety
- Shared responsibility for OHS
- Effective communication.
CPBS Sustainability
1. From time to time, managers can expect staff to perform tasks, not defined specifically in the job description, which will be to the benefit of the general business of the RIIP®/CENQAM®. The tasks will be related to the general business and within the
competency of the staff member and include:
- Promoting quality culture by attending planned training sessions, eliminating quality management system related deficiencies by being actively involved in Investigations, CAPA and Risk management activities, thereby adding value to the QMS.
- Personal ownership, accountability, trust
- Promoting business and customer service targets by: Proper care of business, Time management and planning (including leave trends, working hours) and Dedication towards performing of KPA.
Minimum requirements
MINIMUM REQUIREMENTS:
- A Grade 12 with Science or Mathematics (at at least 40%).
- A minimum of 1 year experience in a Pharmaceutical analytical lab in the case of a degree or diploma in analytical chemistry.
- A minimum of 2 years’ experience in a Pharmaceutical analytical lab in case of Matric (with mathematics & science at least 40%)
FUNCTIONAL / TECHNICAL COMPETENCIES (KNOWLEDGE AND SKILLS)
- Proven knowledge of HPLC analyses, Proven knowledge of Pharmaceutical Quality Management Systems (GMP, ISO 17025).
- Understanding and correctly executing HPLC methods; Adhere to in-house quality system by following:
- SOP’s and Recognising deviations and analytical errors.
- Ability to do pharmaceutical calculations in order to prepare solutions with set molarity or normality.
- Percentage calculations; basic statistics (average SD and %RSD); and equivalence calculations.
BEHAVIOURAL COMPETENCIES
- Hardworking, be able to work as part of a team, punctual.
- Responsible, accountable, ethical.
REMUNERATION:
The annual total remuneration package will be commensurate with the level of appointment as advertised and in line with the NWU policy guidelines.
ENQUIRIES REGARDING JOB CONTENT MAY BE DIRECTED TO: Anita Wessels on 018 299 2325
ENQUIRIES REGARDING RECRUITMENT PROCESS MAY BE DIRECTED TO: Ms Janine Da Gama on 0169103451
CLOSING DATE: 10 November 2023
PLANNED COMMENCEMENT OF DUTIES: 01 January 2024
Kindly take note: applications must be submitted online through the official nwu vacancy website.
Incomplete applications and those submitted through any other platform will not be considered.
The University subscribes to and applies the principles of Employment Equity (EE) Act and is committed to transformation. Preference will be given to candidates from the designated groups, in accordance with the principles of the EE Act and NWU Employment Equity Plan.
The University reserves the right not to make an appointment. Communication will be limited to shortlisted candidates only.
If you are not contacted within two months from the closing date of this advertisement, please accept that your application was unsuccessful.
